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Drug Interactions
In a study in normal volunteers, no interaction of buspirone with amitriptyline was seen. A similar study with buspirone and diazepam showed an increase in the levels of nordiazepam.
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What special precautions should I follow?
Possible Concerns Related to Buspirone's Binding to Dopamine Receptors:
Because buspirone can bind to central dopamine receptors, a question has been raised about its potential to cause acute and
chronic changes in dopamine mediated neurological function (e.g., dystonia, pseudoparkinsonism, akathisia, and tardive dyskinesia). Clinical experience in controlled trials has failed to identify any
significant neuroleptic-like activity; however, a syndrome of restlessness, appearing shortly after initiation of treatment, has been reported in some small fraction of buspirone treated patients. The
syndrome may be explained in several ways.
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Adverse Effects
CNS:
Dizziness, headache, drowsiness, lightheadedness, insomnia, fatigue, nervousness, decreased concentration, excitement, depression, confusion, nightmares/vivid dreams, anger/hostility. Infrequ
ently (<1%) depersonalization, noise intolerance, euphoria/feeling high, dissociative reaction, fear, loss of interest, dysphoria, hallucinations, seizures, suicidal thoughts. Rarely, slurred speech,
claustrophobia, cold intolerance, stupor, psychosis.
Neurologic:
Paresthesia, weakness, incoordination, tremor, numbness. Infrequently, muscle cramps and spasms, rigid/stiff muscles, involu
ntary movements, akathisia, slowed reaction time. Rarely, tingling of limbs, stiff neck, rigidity of jaw, ataxia.
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How to Use
Buspirone comes as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take buspirone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take buspirone even if you fe
el well. Do not stop taking buspirone without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must b
e taken regularly for a few weeks before its full effect is felt.
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DRUG ABUSE AND DEPENDENCE :
In human and animal studies, BUSPAR has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers wi
th a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between BUSPAR and placebo. In addition, stud
ies in monkeys, mice, and rats have indicated that BUSPAR lacks potential for abuse.
Although there is no direct evidence that BUSPAR causes physical dependence or drug-seeking behavior, it i
s difficult to predict from experiments the extent to which a CNS-active drug will be misused.
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Overdosage
- upset stomach
- vomiting
- dizziness
- drowsiness
- blurred vision
- upset stomach
- vomiting
- dizziness
- drowsiness
- blurred vision
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