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Significant Interactions:
Butalbital slows the central nervous system (CNS) and intensifies the effects of alcohol and other CNS depressants. Use of alcohol with this drug may also cause overdose symptoms. Avoid alcoholic beve rages while taking Fioricet.

It is especially important to check with your doctor before combining Fioricet with the following:

- Antihistamines such as Benadryl
- Drugs known as monoamine oxidase inhibitors, including the antidepressants Nardil and Parnate
- Drugs to treat depression such as Elavil
- Major tranquilizers such as Haldol and Thorazine
- Muscle relaxants such as Flexeril
- Narcotic pain relievers such as Darvon
- Sleep aids such as Halcion
- Tranquilizers such as Xanax and Valium

Other medical problems
PregnancyˇX

- For butalbital: Barbiturates such as butalbital have been shown to increase the chance of birth defects in humans. Also, one study in humans has suggested that barbiturates tak n during pregnancy may increase the chance of brain tumors in the baby.Butalbital may cause breathing problems in the newborn baby if taken just before or during delivery.
- For acetaminophen: Al though studies on birth defects with acetaminophen have not been done in pregnant women, it has not been reported to cause birth defects or other problems.
- For caffeine: Use of large amounts of caffeine during pregnancy may cause problems with the heart rhythm and the growth of the fetus.

Possible Side Effect
Fioricet may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recomme nded until you know your response to this drug.

If you are being treated for severe depression or have a history of severe depression or drug abuse, consult with your doctor before taking Fi oricet.

Use this drug with caution if you are elderly or in a weakened condition, if you have liver or kidney problems, or if you have severe abdominal trouble

What is this medicine
Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates that slow down your central nervous system (brain and nerve impulses) causing relaxation. Caff eine is believed to constrict dilated blood vessels that may contribute to tension headaches. Together, acetaminophen, butalbital, and caffeine are used to relieve complex tension (muscle contraction) headaches although precisely how it works is unknown. Acetaminophen / butalbital / caffeine may also be used for purposes other than those listed in this medication guide.

Proper Use of This Medicine
People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor's directions about taking the other medicine, even if you r headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headach es should occur less often, and they should be less severe and easier to relieve than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement afte r several weeks of headache-preventing treatment, check with your doctor.

Overdosage
Seek emergency medical attention. Symptoms of an acetaminophen / butalbital / caffeine - Fioricet overdose include insomnia, restlessness, tremor, nausea, vomiting, diarrhea, abdominal pain, sweating, seizures, drowsiness, decreased breathing,




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